2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W052600
    Ethyl azetidine-3-carboxylate hydrochloride 405090-31-5 98.0%
    Ethyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Ethyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2]
    Ethyl azetidine-3-carboxylate hydrochloride
  • HY-140396
    Aminooxy-PEG3-bromide 1895922-73-2
    Aminooxy-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Aminooxy-PEG3-bromide
  • HY-W109760
    FmocNH-PEG2-CH2CONH-PEG2-CH2COOH 560088-89-3
    FmocNH-PEG2-CH2CONH-PEG2-CH2COOH is an optimized, extended PEG-like linker[1].
    FmocNH-PEG2-CH2CONH-PEG2-CH2COOH
  • HY-141007
    3,4-Dibromo-Mal-PEG8-Boc 2055198-02-0 98.0%
    3,4-Dibromo-Mal-PEG8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    3,4-Dibromo-Mal-PEG8-Boc
  • HY-140465
    Fmoc-NMe-PEG4-C2-acid 2170240-98-7
    Fmoc-NMe-PEG4-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NMe-PEG4-C2-acid
  • HY-135939
    DBCO-NHCO-PEG2-Biotin 2989400-08-8
    DBCO-NHCO-PEG2-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NHCO-PEG2-Biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NHCO-PEG2-Biotin
  • HY-140779
    Azido-PEG6-C2-Boc 406213-76-1 99.77%
    Azido-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-C2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG6-C2-Boc
  • HY-141357
    SPDP-PEG24-NHS ester
    SPDP-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    SPDP-PEG24-NHS ester
  • HY-130182
    Propargyl-PEG8-NH2 1196732-52-1 ≥98.0%
    Propargyl-PEG8-NH2 (compound 3b) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-NH2 is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG8-NH2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG8-NH2
  • HY-141272
    Methyltetrazine-PEG24-NHS ester 99.32%
    Methyltetrazine-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyltetrazine-PEG24-NHS ester
  • HY-141027
    Bis-PEG29-acid
    Bis-PEG29-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-PEG29-acid
  • HY-140806
    Azido-PEG24-alcohol 2415674-94-9 98.0%
    Azido-PEG24-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG24-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG24-alcohol
  • HY-W096086
    Ethyl acetate-PEG1 2093-20-1
    Ethyl acetate-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Ethyl acetate-PEG1
  • HY-141341
    S-acetyl-PEG4-alcohol 223611-42-5
    S-acetyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    S-acetyl-PEG4-alcohol
  • HY-140768
    Azido-PEG3-O-NHS ester 2110448-98-9
    Azido-PEG3-O-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-O-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-O-NHS ester
  • HY-130942
    Bromoacetamide-PEG3-propargyl 932741-11-2
    Bromoacetamide-PEG3-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromoacetamide-PEG3-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bromoacetamide-PEG3-propargyl
  • HY-130489
    Bromo-PEG5-C2-acid 1817735-27-5 98.0%
    Bromo-PEG5-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG5-C2-acid
  • HY-130469
    Mal-PEG4-Boc 518044-36-5 99.93%
    Mal-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG4-Boc
  • HY-130672
    Hydroxy-PEG3-NHS 1807518-71-3
    Hydroxy-PEG3-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hydroxy-PEG3-NHS
  • HY-140381
    Azide-PEG2-MS 176520-23-3
    Azide-PEG2-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG2-Ms is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG2-MS
PROTAC Linkers Isoform Comparison

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